• Theme 1 centers on the transition of health care responsibility from parents to adolescents with chronic illness, treated as a developmental-systems problem. It emphasizes balanced parental involvement, youth autonomy, and perceptions before/after transfer, across several works that examine how families navigate shifting roles [2], [3], [11], [10], [13].

• Theme 2 foregrounds self-management and treatment adherence under chronic illness burden, highlighting youth/parent perspectives, engagement strategies, and education to reduce treatment burden. It spans CF adherence, self-management programs, and mixed-method evaluations of engagement interventions [4], [6], [19], [18], [17].

• Theme 3 analyzes family systems and leadership in pediatric chronic illness care, drawing on MEND, adaptive leadership, and family-centered care models to balance caregiver roles, dynamics, and patient self-management [17], [14], [2], [3], [10].

• Theme 4 investigates quality of care, patient-centered measurement, and psychosocial aspects, using frameworks and mixed-methods to assess hospital care quality, determinants of care, and quality-of-life linkages [16], [9], [5], [7].

• Theme 5 addresses system-level innovations and education for pediatric chronic illness, including health-system transformations, transition-focused research, and education programs to prepare families and providers [8], [15], [11], [16], [20].